Impaired Fibrinolysis in Pregnancy Failure: Impaired Fibrinolysis and Pregnancy Failure

Samina Mohyuddin; Rabab  Zehra; Samar    Ekram; Zareen    Naz; Shahida  Kashif; Badar  Jahan

doi:10.55279/jafmdc.v7i2.441

Impaired Fibrinolysis in Pregnancy Failure

Impaired Fibrinolysis and Pregnancy Failure

Authors

Samina Mohyuddin Karachi institute of medical sciences
Rabab Zehra Liaquat College of Medicine and Dentistry Karachi
Samar Ekram Liaquat College of Medicine and Dentistry Karachi
Zareen Naz Liaquat College of Medicine and Dentistry Karachi
Shahida Kashif Liaquat College of Medicine and Dentistry Karachi
Badar Jahan Shaheed Mohtarma Benazir Bhutto Medical College, KHI, PAK

DOI:

https://doi.org/10.55279/jafmdc.v7i2.441

Keywords:

Fibrinolysis, Miscarriage, Plasminogen Activator Inhibitor-1

Abstract

Objective: To explore the association between plasma plasminogen activator inhibitor 1 (PAI-1) levels and women experiencing recurrent miscarriages with no live births to those who have had one or more live births.

Methodology: This cross-sectional study included healthy women aged 18–35 years with a history of two or more consecutive miscarriages before 20 weeks of gestation, after obtaining ethical approval and informed consent. The study was conducted in a local private hospital in Karachi, Pakistan. Women with medical and reproductive disorders were excluded. Seventy-five females were selected for the collection of blood samples. Plasma Plasminogen Activator Inhibitor-1 (PAI-1) levels were measured using a Human PAI-1 ELISA kit.

Results: Among women with recurrent pregnancy loss, 18.7% had elevated PAI-1 levels, which was significantly correlated with fewer live births (P < 0.05). Notably, 87.5% of those with increased PAI-1 had no live children, while only 12.5% had two or more live children.

Conclusion: Elevated plasma levels of Plasminogen Activator Inhibitor-1 can disrupt fetomaternal circulation and may contribute to recurrent pregnancy loss.

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Published

2025-12-30

How to Cite

Mohyuddin, S., Zehra , R. ., Ekram , S. . ., Naz, Z. . ., Kashif, S. ., & Jahan, B. . (2025). Impaired Fibrinolysis in Pregnancy Failure: Impaired Fibrinolysis and Pregnancy Failure. Journal of Aziz Fatimah Medical & Dental College, 7(2), 45–50. https://doi.org/10.55279/jafmdc.v7i2.441

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Issue

Vol. 7 No. 2 (2025): Journal of Aziz Fatimah Medical and Dental College

Section

Original Articles

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