Initial Systemic Treatment of Advanced Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
DOI:
https://doi.org/10.55279/jafmdc.v1i1.32Keywords:
Non-small cell lung cancer, Immune check point inhibitors, Immunotherapy, Targeted therapy, Chemotherapy.Abstract
The incidence of lung cancer is rising worldwide and cigarette smoking is recognized major risk factor for lung cancer. Non-small cell lung cancer (NSCLC) constitutes majority of all lung cancer cases. The prognosis for NSCLC remains poor. The five-year survival rate for all NSCLC stages combined is 23% and for stage IV NSCLC alone is 6%. The systemic chemotherapy has proved to prolong survival in some patients with advanced NSCLC. The targeted treatments have recently become available for minority of patients with NSCLC due to identification of sensitizing mutations and improved understanding of downstream molecular pathways. The immune check point inhibitors have redefined treatment for majority of NSCLC patients who lack “sensitizing mutations” for targeted agents. This review discusses current standard treatment for advanced NSCLC in first line setting.
Additional Files
Published
How to Cite
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
-
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
-
Non Commercial — You may not use the material for commercial purposes.
-
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
